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Mattxew
It's 16, the first number is odd and the second number is even, unlike the others.

That's what I think.
mreijepatmat
25,16,49,63,81

 It's 63. Why?
We notice that each number is a perfect square at the exception of 63:

5² =25
4² =16
7² =49
9² =81, so the number 63 which is 7 x 9 is the odd man in this series

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